Virtual & Extended Reality for Healthcare  |  Wellovate LLC

Literature Review

With over 20 years of clinical research, VR has repeatedly demonstrated to be a safe and effective tool for multiple scenerios.

Gupta A, Scott K, Dukewich M. Innovative Technology Using Virtual Reality in the Treatment of Pain: Does It Reduce Pain via Distraction, or Is There More to It? Pain Med. 2018;19(1):151‐159.

Hoffman HG, et al. Virtual Reality as an Adjunctive Non-pharmacologic Analgesic for Acute Burn Pain During Medical Procedures. Ann Behav Med. 2011 Apr;41(2):183-91.

Hoffman HG, Patterson DR, Soltani M, et al. Virtual reality pain control during physical therapy range of motion exercises for a patient with multiple blunt force trauma injuries. Cyberpsychol Behav. 2009;12(1):47‐49.

Jones T, Moore T, Choo J. The impact of virtual reality on chronic pain. PLoS One. 2016;11(12).

Kenney MP, Milling, LS. The effectiveness of virtual reality distraction for reducing pain: A meta-analysis. Psychology of Consciousness: Theory, Research, and Practice. 2016;3(3): 199-210.

Morris LD, Louw QA, Grimmer-Somers K. The effectiveness of virtual reality on reducing pain and anxiety in burn injury patients: a systematic review. Clin J Pain. 2009;25(9):815‐826.

Malloy KM, Milling LS. The effectiveness of virtual reality distraction for pain reduction: a systematic review. Clin Psychol Rev. 2010;30(8):1011‐1018.

Pourmand A, Davis S. Virtual reality as a clinical tool for pain management. Current Pain and Headache Reports. 2018;22(8):53.

Osumi M, Inomata K, Inoue Y, et al. Characteristics of Phantom Limb Pain Alleviated with Virtual Reality Rehabilitation. Pain Med. 2019;20(5):1038-1046.

Tashjian VC, Mosadeghi S, Howard AR, et al. Virtual Reality for Management of Pain in Hospitalized Patients: Results of a Controlled Trial. JMIR Ment Health. 2017;4(1):e9.

Trost Z, Zielke M, Guck A, et al. The promise and challenge of virtual gaming technologies for chronic pain: the case of graded exposure for low back pain. Pain Manag. 2015;5(3):197‐206.

Banos R, Espinoza M, et al. A positive psychological intervention using virtual reality for patients with advanced cancer in hospital setting: a pilot study to assess feasibility. Supportive Care in Cancer. 2013;21(1):263-270.

Chirico A, Lucidi F, De Laurentiis M, Milanese C, Napoli A, Giordano A. Virtual Reality in Health System: Beyond Entertainment. A Mini-Review on the Efficacy of VR During Cancer Treatment. J Cell Physiol. 2016;231(2):275-287.

Gordon EM, Li BM, et al. RELAX: An immersion virtual reality relaxation intervention for quality of life improvement in cancer patients. Journal of Clinical Oncology. 2018;36(34):152-152.

Johnson T, Bauler L, Vos D, et al. Virtual Reality Use for Symptom Management in Palliative Care: A Pilot Study to Assess User Perceptions. J Palliat Med. 2020;10.

Mohammad BE, Ahmad M. Virtual reality as a distraction technique for pain and anxiety among patients with breast cancer: A randomized control trial. Palliative & Supportive Care. 2019;17(1):29-34.

Niki K, Okamoto Y, et al. A novel palliative care approach using virtual reality for improving various symptoms of terminal cancer Patients: A preliminary prospective, multicenter study. Journal of Palliative Medicine. 2019;22(6).

Schneider SM, Kisby CK, Flint EP. Effect of virtual reality on time perception in patients receiving chemotherapy. Supportive Care in Cancer. 2011;19(4):555-564.

Wang SSY, Teo WZW, Teo WZY, Chai YW. Virtual Reality as a Bridge in Palliative Care during COVID-19. J Palliat Med. 2020;23(6):756.

Zeng Y, Zhang JE, Cheng ASK, et al. Meta-Analysis of the Efficacy of Virtual Reality-Based Interventions in Cancer-Related Symptom Management. Integr Cancer Ther. 2019;18.

Birnie KA, et al. Usability Testing of an Interactive Virtual Reality Distraction Intervention to Reduce Procedural Pain in Children and Adolescents With Cancer. J Pediatr Oncol Nurs. 2018;35(6):406‐416.

Chan E, Hovenden M, Ramage E, et al. Virtual Reality for Pediatric Needle Procedural Pain: Two Randomized Clinical Trials. J Pediatr. 2019;209:160‐167.

Das DA, Grimmer KA, et al. The efficacy of playing a virtual reality game in modulating pain for children with acute burn injuries: a randomized controlled trial. BMC Pediatr. 2005 Mar 3;5(1):1.

Gold JI, Mahrer NE. Is Virtual Reality Ready for Prime Time in the Medical Space? A Randomized Control Trial of Pediatric Virtual Reality for Acute Procedural Pain Management. J Pediatr Psychol. 2018;43(3):266‐275.

Eijlers R, Utens EMWJ, Staals LM, et al. Systematic Review and Meta-analysis of Virtual Reality in Pediatrics: Effects on Pain and Anxiety. Anesth Analg. 2019;129(5):1344‐1353.

Hua Y, et al. The Effect of Virtual Reality Distraction on Pain Relief During Dressing Changes in Children with Chronic Wounds on Lower Limbs. Pain Manag Nurs. 2015;16(5):685‐691.

Nilsson S, Finnström B, Kokinsky E, Enskär K. The use of Virtual Reality for needle-related procedural pain and distress in children and adolescents in a paediatric oncology unit. Eur J Oncol Nurs. 2009;13(2):102‐109.

Piskorz J, Czub M. Effectiveness of a virtual reality intervention to minimize pediatric stress and pain intensity during venipuncture. J Spec Pediatr Nurs. 2018;23(1):10.

Rao DG, Havale R, Nagaraj M, et al. Assessment of Efficacy of Virtual Reality Distraction in Reducing Pain Perception and Anxiety in Children Aged 6-10 Years: A Behavioral Interventional Study. Int J Clin Pediatr Dent. 2019;12(6):510‐513.

van Twillert B, Bremer M, Faber AW. Computer-generated virtual reality to control pain and anxiety in pediatric and adult burn patients during wound dressing changes. J Burn Care Res. 2007;28(5):694‐702.